Continuity: In the scene where the lizard and Spiderman are fighting in the sewers, the lizard scratches Spider-Man's chest, causing tears down the front of his suit and chest. He actually scratches straight down his chest, but from then on, whenever Spiderman's chest is shown the scratches are diagonally across him.
Continuity: Just when Peter tries the web launcher the tables and chairs on the street change number and position through shots: They are arranged parallel to each other and have the following amount of chairs: First table has 3 chairs, second 2, third 1 and fourth 2. In the close-up, all tables have 2 chairs; the first three tables are parallel, yet a fourth one is behind the third table. Peter also knocks down a table or chair which appears standing in the final shot.
Continuity: During The Lizard's attack on the bridge, he throws the car with Doctor Ratha in off a bridge. Peter then catches the car with a web. Yet as soon as he notices The Lizard, not only is the web not in his hand anymore, but there's no sign of it hanging over the bridge either. Then the web and car reappear in the wide shot where Peter swings over to get the boy out of the car.
Continuity: When Peter throws the trophy out of the window during the fight between him and The Lizard, we can see that it breaks up and the damage of the trophy is all next to each other. But when he throws Gwen out of the window in a web, the damage from the trophy is at least a few feet away from each other.